Priligy

Priligy is a drug used in the treatment of erectile dysfunction and premature ejaculation. The active ingredient is dapoxetine.

Indications for use

Treatment of premature ejaculation (PE) in adult men aged 18 to 64.

Priligy is prescribed only to patients who meet the following criteria:

• latent time of intravaginal ejaculation (IELT) is less than two minutes;
• persistent or repeated ejaculation after minimal sexual stimulation before, during or shortly after sexual penetration, which occurs earlier than the moment desired by the patient;
• severe stress or difficulties that arose in interpersonal relationships as a result of PE;
• insufficient control over the onset of ejaculation;
• the onset of premature ejaculation in most attempts at intercourse in the last 6 months.

Priligy should be taken as needed only as a treatment – before the intended sexual intercourse. Priligy should not be used to delay ejaculation in men who have not been diagnosed with PE.

How it works

Priligy or dapoxetine reduces the rate of serotonin reuptake by neurons and enhances the effect of this neurotransmitter on receptors in the spinal cord that are responsible for sexual arousal and the onset of ejaculation. Dapoxetine reduces the conduction of nerve fibers, increasing the duration of intercourse.

The active substance is rapidly absorbed. The maximum concentration in the blood is observed 1-2 hours after taking the pill. Metabolites are excreted within 19 hours through the organs of the urinary system.

How to use Priligy

Dapoxetine tablets are taken whole without chewing. The presence of food in the stomach does not affect its absorption. The drug should be taken with a large volume of water.

The effective dosage is selected individually. But it is recommended to start with 30 mg of the drug (1/2 tablet) 1-3 hours before the expected sexual intercourse.

In case of insufficient effectiveness, the dose is increased to 60 mg (1 tablet) per day. The maximum allowable amount is 90 mg, but only as directed by a doctor and obese men.

The effectiveness of dapoxetine preparations is evaluated after 1 month or after at least 6 doses. Within six months, the dosage is being revised.

Contraindications

• Hypersensitivity to the active substance or to any excipient of the drug;
• Heart failure (NYHA classes II-IV);
• Conduction abnormalities such as AV block or sick sinus syndrome;
• Severe ischemic heart disease;
• Severe lack of heart valves;
• A history of fainting;
• A history of mania or severe depression;
• Concomitant use of MAO inhibitors or if less than 14 days have passed since stopping them. The use of Priligy should be discontinued at least 7 days before starting therapy with MAO inhibitors;
• Concomitant use of thioridazine or within 14 days after the end of admission. The use of Priligy should be discontinued at least 7 days before starting thioridazine therapy;
• Concomitant use of serotonin reuptake inhibitors (selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs)) or other medicinal / herbal medicines with serotoninergic action [triptans, tramadol, linezolid, lithium, St. John’s wort (Hypericum perforatum)] or within 14 days after discontinuation of these drugs / herbal preparations. These medicines / herbal products should not be taken for 7 days after you stop taking Priligy;
• Concomitant use of potent CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir, atazanavir, and the like;
• Moderate or severe liver dysfunction.

Side effects

The side effects of Priligy and its generics are dose-dependent. Increasing doses provokes unpleasant symptoms.

Frequent complaints from men:

• nausea;
• vertigo and headaches;
• violation of defecation;
• arterial hypertension;
• insomnia;
• stomach ache;
• flatulence;
• impotence;
• bruxism;
• anorgasmia;
• decreased libido;
• nightmares;
• tremor;
• increased fatigue;
• drowsiness, impaired attention;
• fainting.

Abrupt withdrawal of dapoxetine drugs is prohibited, as it may provoke withdrawal syndrome. Typical signs are irritability, anxiety, paresthesia, confusion, insomnia, headaches.

Overdose

Overdose cases are not described in medical statistics. Dapoxetine is thought to increase the risk of side effects from the drug. Treatment is symptomatic. Dialysis, blood transfusion, plasmapheresis are ineffective.

Drug interactions

Do not use Priligy simultaneously with antidepressants, anticonvulsants, hypnotics, tranquilizers, antimycotics.

Driving a car

Dapoxetine preparations can cause fainting, dizziness. Therefore, it is not recommended to drive a car, to perform precise work against its background.

Storage

Store the medicine in its original packaging at a temperature not exceeding 77 °F. Do not freeze, keep away from children and pets.